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Cardioactive effects of diphenhydramine and curcumin in Daphnia magna

Institution: Ursinus College, Collegeville, Pennsylvania

Published onOct 14, 2009
Cardioactive effects of diphenhydramine and curcumin in Daphnia magna

Abstract: Although used as a model for examining the cardioactive effects of various compounds, the neuromuscular regulation of the heart of the crustacean Daphnia magna (D. magna) is not well understood. In the present study, we sought to determine how the heart rate of D. magna was affected by two previously untested compounds: curcumin and diphenhydramine (DPHM). DPHM produces a number of cardiotoxic side effects in vertebrates, particularly sinus tachycardia. Curcumin acts as a monoamine oxidase inhibitor (MAOI) and was expected to increase the heart rate of D. magna. DPHM was found unexpectedly to lower the heart rate of D. magna with time. Curcumin increased heart rate when administered in higher concentrations. However, co-administration of curcumin with DPHM negated this effect. These findings may be explained by the potential role of histamine as a sympathetic cardiac neurotransmitter in D. magna.

Please note: the original article had a citation error that has now been corrected in this version of the article. If you wish to see the originally posted article, please contact the journal at [email protected].

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