Skip to main content
SearchLoginLogin or Signup

The effects of amyloid β-protein on the proliferation of human lung papillary adenocarcinoma

Institution: Brigham Young University-Hawaii, Laie, Hawaii; Brigham Young University, Provo, Utah; Faculty of Sciences, Brigham Young University-Hawaii, Laie, Hawaii

Published onJan 31, 2020
The effects of amyloid β-protein on the proliferation of human lung papillary adenocarcinoma

Abstract: Alzheimer’s Disease (AD) is one of the most prevalent forms of dementia. Previous studies have shown Alzheimer’s Disease is linked with an increase in the concentration of amyloid β-protein (Aβ); recent studies indicate an infection hypothesis could explain the presence and function of amyloid β-protein as an antimicrobial peptide with additional anti-cancer properties. In this study, the anticancer properties were measured by analyzing the effects of Aβ on the in vitro cell growth of papillary adenocarcinoma from the human lung tissue line (H441). Cells were cultured in varying concentrations of Aβ protein for a period of 48 hours under standard cell culturing conditions. The results yielded a significant (p<0.0001) inhibition of cell proliferation.

Keywords: Amyloid β Protein; Alzheimer’s Disease; Infection hypothesis; Cell Proliferation; Anticancer; Antimicrobial

Download Full Article (PDF)

Comments
0
comment

No comments here

Why not start the discussion?